SARS-CoV-2 in Spanish Intensive Care Units: Early experience with 15-day survival in Vitoria.
Identifieur interne : 000680 ( Main/Exploration ); précédent : 000679; suivant : 000681SARS-CoV-2 in Spanish Intensive Care Units: Early experience with 15-day survival in Vitoria.
Auteurs : Helena Barrasa [Espagne] ; Jordi Rello [France] ; Sofia Tejada [Espagne] ; Alejandro Martín [Espagne] ; Goiatz Balziskueta [Espagne] ; Cristina Vinuesa [Espagne] ; Borja Fernández-Miret [Espagne] ; Ana Villagra [Espagne] ; Ana Vallejo [Espagne] ; Ana San Sebastián [Espagne] ; Sara Caba Es [Espagne] ; Sebastián Iribarren [Espagne] ; Fernando Fonseca [Espagne] ; Javier Maynar [Espagne]Source :
- Anaesthesia, critical care & pain medicine [ 2352-5568 ] ; 2020.
Abstract
PURPOSE
Community transmission of SARS-CoV-2 was detected in Spain in February 2020, with 216% intensive care unit (ICU) capacity expanded in Vitoria by March 18
METHODS
We identified patients from the two public hospitals in Vitoria who were admitted to ICU with confirmed infection by SARS-CoV-2. Data reported here were available in April 6th, 2020. Mortality was assessed in those who completed 15-days of ICU stay.
RESULTS
We identified 48 patients (27 males) with confirmed SARS-CoV-2. Median [interquartile range (IQR)] age of patients was 63 [51-75] years. Symptoms began a median of 7 [5-12] days before ICU admission. The most common comorbidities identified were obesity (48%), arterial hypertension (44%) and chronic lung disease (37%). All patients were admitted by hypoxemic respiratory failure and none received non-invasive mechanical ventilation. Forty-five (94%) underwent intubation, 3 (6%) high flow nasal therapy (HFNT), 1 (2%) extracorporeal membrane oxygenation (ECMO) and 22 (46%) required prone position. After 15 days, 14/45 (31%) intubated patients died (13% within one week), 10/45 (22%) were extubated, and 21/45 (47%) underwent mechanical ventilation. Six patients had documented super-infection. Procalcitonin plasma above 0.5μg/L was associated with 16% vs. 19% (p=0.78) risk of death after 7 days.
CONCLUSION
This early experience with SARS-CoV-2 in Spain suggests that a strategy of right oxygenation avoiding non-invasive mechanical ventilation was life-saving. Seven-day mortality in SARS-CoV-2 requiring intubation was lower than 15%, with 80% of patients still requiring mechanical ventilation. After 15 days of ICU admission, half of patients remained intubated, whereas one third died.
DOI: 10.1016/j.accpm.2020.04.001
PubMed: 32278670
PubMed Central: PMC7144603
Affiliations:
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sortKey="Balziskueta, Goiatz" sort="Balziskueta, Goiatz" uniqKey="Balziskueta G" first="Goiatz" last="Balziskueta">Goiatz Balziskueta</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Vinuesa, Cristina" sort="Vinuesa, Cristina" uniqKey="Vinuesa C" first="Cristina" last="Vinuesa">Cristina Vinuesa</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Miret, Borja" sort="Fernandez Miret, Borja" uniqKey="Fernandez Miret B" first="Borja" last="Fernández-Miret">Borja Fernández-Miret</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Villagra, Ana" sort="Villagra, Ana" uniqKey="Villagra A" first="Ana" last="Villagra">Ana Villagra</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Vallejo, Ana" sort="Vallejo, Ana" uniqKey="Vallejo A" first="Ana" last="Vallejo">Ana Vallejo</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="San Sebastian, Ana" sort="San Sebastian, Ana" uniqKey="San Sebastian A" first="Ana" last="San Sebastián">Ana San Sebastián</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Caba Es, Sara" sort="Caba Es, Sara" uniqKey="Caba Es S" first="Sara" last="Caba Es">Sara Caba Es</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Iribarren, Sebastian" sort="Iribarren, Sebastian" uniqKey="Iribarren S" first="Sebastián" last="Iribarren">Sebastián Iribarren</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Fonseca, Fernando" sort="Fonseca, Fernando" uniqKey="Fonseca F" first="Fernando" last="Fonseca">Fernando Fonseca</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Maynar, Javier" sort="Maynar, Javier" uniqKey="Maynar J" first="Javier" last="Maynar">Javier Maynar</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32278670</idno><idno type="pmid">32278670</idno><idno type="doi">10.1016/j.accpm.2020.04.001</idno><idno type="pmc">PMC7144603</idno><idno type="wicri:Area/Main/Corpus">001752</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001752</idno><idno type="wicri:Area/Main/Curation">001752</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001752</idno><idno type="wicri:Area/Main/Exploration">001752</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">SARS-CoV-2 in Spanish Intensive Care Units: Early experience with 15-day survival in Vitoria.</title><author><name sortKey="Barrasa, Helena" sort="Barrasa, Helena" uniqKey="Barrasa H" first="Helena" last="Barrasa">Helena Barrasa</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name><affiliation wicri:level="3"><nlm:affiliation>Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos II, Madrid, Spain; Clinical Research in Pneumonia & Sepsis (CRIPS), Vall d'Hebron Institute of Research, Barcelona, Spain; Clinical Research, CHU Nîmes, University Montpellier - Nîmes, Nîmes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos II, Madrid, Spain; Clinical Research in Pneumonia & Sepsis (CRIPS), Vall d'Hebron Institute of Research, Barcelona, Spain; Clinical Research, CHU Nîmes, University Montpellier - Nîmes, Nîmes</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName></affiliation></author><author><name sortKey="Tejada, Sofia" sort="Tejada, Sofia" uniqKey="Tejada S" first="Sofia" last="Tejada">Sofia Tejada</name><affiliation wicri:level="3"><nlm:affiliation>Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos II, Madrid, Spain; Clinical Research in Pneumonia & Sepsis (CRIPS), Vall d'Hebron Institute of Research, Barcelona, Spain. Electronic address: stmagraner@gmail.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos II, Madrid, Spain; Clinical Research in Pneumonia & Sepsis (CRIPS), Vall d'Hebron Institute of Research, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martin, Alejandro" sort="Martin, Alejandro" uniqKey="Martin A" first="Alejandro" last="Martín">Alejandro Martín</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Balziskueta, Goiatz" sort="Balziskueta, Goiatz" uniqKey="Balziskueta G" first="Goiatz" last="Balziskueta">Goiatz Balziskueta</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Vinuesa, Cristina" sort="Vinuesa, Cristina" uniqKey="Vinuesa C" first="Cristina" last="Vinuesa">Cristina Vinuesa</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Miret, Borja" sort="Fernandez Miret, Borja" uniqKey="Fernandez Miret B" first="Borja" last="Fernández-Miret">Borja Fernández-Miret</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Villagra, Ana" sort="Villagra, Ana" uniqKey="Villagra A" first="Ana" last="Villagra">Ana Villagra</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Vallejo, Ana" sort="Vallejo, Ana" uniqKey="Vallejo A" first="Ana" last="Vallejo">Ana Vallejo</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="San Sebastian, Ana" sort="San Sebastian, Ana" uniqKey="San Sebastian A" first="Ana" last="San Sebastián">Ana San Sebastián</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Caba Es, Sara" sort="Caba Es, Sara" uniqKey="Caba Es S" first="Sara" last="Caba Es">Sara Caba Es</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Iribarren, Sebastian" sort="Iribarren, Sebastian" uniqKey="Iribarren S" first="Sebastián" last="Iribarren">Sebastián Iribarren</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Fonseca, Fernando" sort="Fonseca, Fernando" uniqKey="Fonseca F" first="Fernando" last="Fonseca">Fernando Fonseca</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author><author><name sortKey="Maynar, Javier" sort="Maynar, Javier" uniqKey="Maynar J" first="Javier" last="Maynar">Javier Maynar</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Hospital Universitario de Alava</wicri:regionArea><wicri:noRegion>Hospital Universitario de Alava</wicri:noRegion></affiliation></author></analytic><series><title level="j">Anaesthesia, critical care & pain medicine</title><idno type="eISSN">2352-5568</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b></p><p>Community transmission of SARS-CoV-2 was detected in Spain in February 2020, with 216% intensive care unit (ICU) capacity expanded in Vitoria by March 18</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We identified patients from the two public hospitals in Vitoria who were admitted to ICU with confirmed infection by SARS-CoV-2. Data reported here were available in April 6th, 2020. Mortality was assessed in those who completed 15-days of ICU stay.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We identified 48 patients (27 males) with confirmed SARS-CoV-2. Median [interquartile range (IQR)] age of patients was 63 [51-75] years. Symptoms began a median of 7 [5-12] days before ICU admission. The most common comorbidities identified were obesity (48%), arterial hypertension (44%) and chronic lung disease (37%). All patients were admitted by hypoxemic respiratory failure and none received non-invasive mechanical ventilation. Forty-five (94%) underwent intubation, 3 (6%) high flow nasal therapy (HFNT), 1 (2%) extracorporeal membrane oxygenation (ECMO) and 22 (46%) required prone position. After 15 days, 14/45 (31%) intubated patients died (13% within one week), 10/45 (22%) were extubated, and 21/45 (47%) underwent mechanical ventilation. Six patients had documented super-infection. Procalcitonin plasma above 0.5μg/L was associated with 16% vs. 19% (p=0.78) risk of death after 7 days.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>This early experience with SARS-CoV-2 in Spain suggests that a strategy of right oxygenation avoiding non-invasive mechanical ventilation was life-saving. Seven-day mortality in SARS-CoV-2 requiring intubation was lower than 15%, with 80% of patients still requiring mechanical ventilation. After 15 days of ICU admission, half of patients remained intubated, whereas one third died.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32278670</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2352-5568</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Apr</Month><Day>09</Day></PubDate></JournalIssue><Title>Anaesthesia, critical care & pain medicine</Title><ISOAbbreviation>Anaesth Crit Care Pain Med</ISOAbbreviation></Journal><ArticleTitle>SARS-CoV-2 in Spanish Intensive Care Units: Early experience with 15-day survival in Vitoria.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S2352-5568(20)30064-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.accpm.2020.04.001</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Community transmission of SARS-CoV-2 was detected in Spain in February 2020, with 216% intensive care unit (ICU) capacity expanded in Vitoria by March 18<sup>th</sup>, 2020.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We identified patients from the two public hospitals in Vitoria who were admitted to ICU with confirmed infection by SARS-CoV-2. Data reported here were available in April 6th, 2020. Mortality was assessed in those who completed 15-days of ICU stay.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We identified 48 patients (27 males) with confirmed SARS-CoV-2. Median [interquartile range (IQR)] age of patients was 63 [51-75] years. Symptoms began a median of 7 [5-12] days before ICU admission. The most common comorbidities identified were obesity (48%), arterial hypertension (44%) and chronic lung disease (37%). All patients were admitted by hypoxemic respiratory failure and none received non-invasive mechanical ventilation. Forty-five (94%) underwent intubation, 3 (6%) high flow nasal therapy (HFNT), 1 (2%) extracorporeal membrane oxygenation (ECMO) and 22 (46%) required prone position. After 15 days, 14/45 (31%) intubated patients died (13% within one week), 10/45 (22%) were extubated, and 21/45 (47%) underwent mechanical ventilation. Six patients had documented super-infection. Procalcitonin plasma above 0.5μg/L was associated with 16% vs. 19% (p=0.78) risk of death after 7 days.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This early experience with SARS-CoV-2 in Spain suggests that a strategy of right oxygenation avoiding non-invasive mechanical ventilation was life-saving. Seven-day mortality in SARS-CoV-2 requiring intubation was lower than 15%, with 80% of patients still requiring mechanical ventilation. After 15 days of ICU admission, half of patients remained intubated, whereas one third died.</AbstractText><CopyrightInformation>Copyright © 2020 Société française d'anesthésie et de réanimation (Sfar). Published by Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Barrasa</LastName><ForeName>Helena</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rello</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos II, Madrid, Spain; Clinical Research in Pneumonia & Sepsis (CRIPS), Vall d'Hebron Institute of Research, Barcelona, Spain; Clinical Research, CHU Nîmes, University Montpellier - Nîmes, Nîmes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tejada</LastName><ForeName>Sofia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos II, Madrid, Spain; Clinical Research in Pneumonia & Sepsis (CRIPS), Vall d'Hebron Institute of Research, Barcelona, Spain. Electronic address: stmagraner@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martín</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balziskueta</LastName><ForeName>Goiatz</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vinuesa</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández-Miret</LastName><ForeName>Borja</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villagra</LastName><ForeName>Ana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vallejo</LastName><ForeName>Ana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>San Sebastián</LastName><ForeName>Ana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cabañes</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iribarren</LastName><ForeName>Sebastián</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fonseca</LastName><ForeName>Fernando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maynar</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hospital Universitario de Alava, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Alava COVID-19 Study Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Anaesth Crit Care Pain Med</MedlineTA><NlmUniqueID>101652401</NlmUniqueID><ISSNLinking>2352-5568</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ARDS</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Pneumonia</Keyword><Keyword MajorTopicYN="N">Procalcitonin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32278670</ArticleId><ArticleId IdType="pii">S2352-5568(20)30064-3</ArticleId><ArticleId IdType="doi">10.1016/j.accpm.2020.04.001</ArticleId><ArticleId IdType="pmc">PMC7144603</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Am J Respir Crit Care Med. 2020 May 15;201(10):1299-1300</Citation><ArticleIdList><ArticleId IdType="pubmed">32228035</ArticleId></ArticleIdList></Reference><Reference><Citation>Anaesth Crit Care Pain Med. 2020 Apr;39(2):167-169</Citation><ArticleIdList><ArticleId IdType="pubmed">32142972</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Mar 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May;8(5):475-481</Citation><ArticleIdList><ArticleId IdType="pubmed">32105632</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2019 Nov;17(11):1989-1994</Citation><ArticleIdList><ArticleId IdType="pubmed">31410983</ArticleId></ArticleIdList></Reference><Reference><Citation>Travel Med Infect Dis. 2020 Mar - Apr;34:101623</Citation><ArticleIdList><ArticleId IdType="pubmed">32179124</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2009;13(5):R148</Citation><ArticleIdList><ArticleId IdType="pubmed">19747383</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Mar 19;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32191259</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2020 May;18(5):1094-1099</Citation><ArticleIdList><ArticleId IdType="pubmed">32220112</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li><li>France</li></country><region><li>Catalogne</li><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li></region><settlement><li>Barcelone</li><li>Nîmes</li></settlement></list><tree><country name="Espagne"><noRegion><name sortKey="Barrasa, Helena" sort="Barrasa, Helena" uniqKey="Barrasa H" first="Helena" last="Barrasa">Helena Barrasa</name></noRegion><name sortKey="Balziskueta, Goiatz" sort="Balziskueta, Goiatz" uniqKey="Balziskueta G" first="Goiatz" last="Balziskueta">Goiatz Balziskueta</name><name sortKey="Caba Es, Sara" sort="Caba Es, Sara" uniqKey="Caba Es S" first="Sara" last="Caba Es">Sara Caba Es</name><name sortKey="Fernandez Miret, Borja" sort="Fernandez Miret, Borja" uniqKey="Fernandez Miret B" first="Borja" last="Fernández-Miret">Borja Fernández-Miret</name><name sortKey="Fonseca, Fernando" sort="Fonseca, Fernando" uniqKey="Fonseca F" first="Fernando" last="Fonseca">Fernando Fonseca</name><name sortKey="Iribarren, Sebastian" sort="Iribarren, Sebastian" uniqKey="Iribarren S" first="Sebastián" last="Iribarren">Sebastián Iribarren</name><name sortKey="Martin, Alejandro" sort="Martin, Alejandro" uniqKey="Martin A" first="Alejandro" last="Martín">Alejandro Martín</name><name sortKey="Maynar, Javier" sort="Maynar, Javier" uniqKey="Maynar J" first="Javier" last="Maynar">Javier Maynar</name><name sortKey="San Sebastian, Ana" sort="San Sebastian, Ana" uniqKey="San Sebastian A" first="Ana" last="San Sebastián">Ana San Sebastián</name><name sortKey="Tejada, Sofia" sort="Tejada, Sofia" uniqKey="Tejada S" first="Sofia" last="Tejada">Sofia Tejada</name><name sortKey="Vallejo, Ana" sort="Vallejo, Ana" uniqKey="Vallejo A" first="Ana" last="Vallejo">Ana Vallejo</name><name sortKey="Villagra, Ana" sort="Villagra, Ana" uniqKey="Villagra A" first="Ana" last="Villagra">Ana Villagra</name><name sortKey="Vinuesa, Cristina" sort="Vinuesa, Cristina" uniqKey="Vinuesa C" first="Cristina" last="Vinuesa">Cristina Vinuesa</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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